Methionine Oxidation Changes the Mechanism of Aβ Peptide Binding to the DMPC Bilayer

Using all-atom explicit solvent replica exchange molecular dynamics simulations with solute tempering, we study the effect of methionine oxidation on Aβ10–40 peptide binding to the zwitterionic DMPC bilayer. By comparing oxidized and reduced peptides, we identified changes in the binding mechanism c...

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Detalles Bibliográficos
Autores principales: Lockhart, Christopher, Smith, Amy K., Klimov, Dmitri K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459879/
https://www.ncbi.nlm.nih.gov/pubmed/30976055
http://dx.doi.org/10.1038/s41598-019-42304-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459879/
https://www.ncbi.nlm.nih.gov/pubmed/30976055
http://dx.doi.org/10.1038/s41598-019-42304-9

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