Signal-induced PARP1-Erk synergism mediates IEG expression

A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-in...

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Autores principales: Cohen-Armon, Malka, Yeheskel, Adva, Pascal, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459926/
https://www.ncbi.nlm.nih.gov/pubmed/30993015
http://dx.doi.org/10.1038/s41392-019-0042-0
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author Cohen-Armon, Malka
Yeheskel, Adva
Pascal, John M.
author_facet Cohen-Armon, Malka
Yeheskel, Adva
Pascal, John M.
author_sort Cohen-Armon, Malka
collection PubMed
description A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy.
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spelling pubmed-64599262019-04-16 Signal-induced PARP1-Erk synergism mediates IEG expression Cohen-Armon, Malka Yeheskel, Adva Pascal, John M. Signal Transduct Target Ther Review Article A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy. Nature Publishing Group UK 2019-04-12 /pmc/articles/PMC6459926/ /pubmed/30993015 http://dx.doi.org/10.1038/s41392-019-0042-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Cohen-Armon, Malka
Yeheskel, Adva
Pascal, John M.
Signal-induced PARP1-Erk synergism mediates IEG expression
title Signal-induced PARP1-Erk synergism mediates IEG expression
title_full Signal-induced PARP1-Erk synergism mediates IEG expression
title_fullStr Signal-induced PARP1-Erk synergism mediates IEG expression
title_full_unstemmed Signal-induced PARP1-Erk synergism mediates IEG expression
title_short Signal-induced PARP1-Erk synergism mediates IEG expression
title_sort signal-induced parp1-erk synergism mediates ieg expression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459926/
https://www.ncbi.nlm.nih.gov/pubmed/30993015
http://dx.doi.org/10.1038/s41392-019-0042-0
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