Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography
PURPOSE: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by (15)O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery diseas...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Society for Magnetic Resonance in Medicine
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460128/ https://www.ncbi.nlm.nih.gov/pubmed/30047496 http://dx.doi.org/10.2463/mrms.mp.2018-0003 |
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author | Kikuchi, Yasuka Naya, Masanao Oyama-Manabe, Noriko Manabe, Osamu Sugimori, Hiroyuki Kudo, Kohsuke Kato, Fumi Aikawa, Tadao Tsutsui, Hiroyuki Tamaki, Nagara Shirato, Hiroki |
author_facet | Kikuchi, Yasuka Naya, Masanao Oyama-Manabe, Noriko Manabe, Osamu Sugimori, Hiroyuki Kudo, Kohsuke Kato, Fumi Aikawa, Tadao Tsutsui, Hiroyuki Tamaki, Nagara Shirato, Hiroki |
author_sort | Kikuchi, Yasuka |
collection | PubMed |
description | PURPOSE: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by (15)O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. METHODS: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. RESULTS: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R(2) = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. CONCLUSION: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material. |
format | Online Article Text |
id | pubmed-6460128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Japanese Society for Magnetic Resonance in Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-64601282019-04-15 Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography Kikuchi, Yasuka Naya, Masanao Oyama-Manabe, Noriko Manabe, Osamu Sugimori, Hiroyuki Kudo, Kohsuke Kato, Fumi Aikawa, Tadao Tsutsui, Hiroyuki Tamaki, Nagara Shirato, Hiroki Magn Reson Med Sci Major Paper PURPOSE: The aim of this study was to verify coronary flow velocity reserve (CFVR) on the left main trunk (LMT) in comparison with myocardial flow reserve (MFR) by (15)O-labeled water positron emission tomography (PET) (MFR-PET) in both the healthy adults and the patients with coronary artery disease (CAD), and to evaluate the feasibility of CFVR to detect CAD. METHODS: Eighteen healthy adults and 13 patients with CAD were evaluated. CFVR in LMT was estimated by 3T magnetic resonance imaging (MRI) with phase contrast technique. MFR-PET in the LMT territory including anterior descending artery and circumflex artery was calculated as the ratio of myocardial blood flow (MBF)-PET at stress to MBF-PET at rest. RESULTS: There was a significant positive relationship between CFVR and MFR-PET (R = 0.45, P < 0.0001). Inter-observer calculations of CFVR showed good correlation (R(2) = 0.93, P < 0.0001). The CFVR in patients with CAD was significantly lower than that in healthy adults (1.90 ± 0.61 vs. 2.77 ± 1.03, respectively, P = 0.01), which were similar to the results of MFR-PET (2.23 ± 0.84 vs. 3.96 ± 1.04, respectively, P < 0.0001). For the detection of patients with CAD, the area under the curve was 0.78 (P = 0.01). The sensitivity was 0.77 and specificity was 0.72 when a cut-off of 2.15 was used. CONCLUSION: CFVR by 3T was validated with MFR-PET. CFVR could detect the patients with CAD. This method is a simple and reliable index without radiation or contrast material. Japanese Society for Magnetic Resonance in Medicine 2018-07-26 /pmc/articles/PMC6460128/ /pubmed/30047496 http://dx.doi.org/10.2463/mrms.mp.2018-0003 Text en © 2018 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Major Paper Kikuchi, Yasuka Naya, Masanao Oyama-Manabe, Noriko Manabe, Osamu Sugimori, Hiroyuki Kudo, Kohsuke Kato, Fumi Aikawa, Tadao Tsutsui, Hiroyuki Tamaki, Nagara Shirato, Hiroki Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography |
title | Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography |
title_full | Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography |
title_fullStr | Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography |
title_full_unstemmed | Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography |
title_short | Assessment of Coronary Flow Velocity Reserve in the Left Main Trunk Using Phase-contrast MR Imaging at 3T: Comparison with (15)O-labeled Water Positron Emission Tomography |
title_sort | assessment of coronary flow velocity reserve in the left main trunk using phase-contrast mr imaging at 3t: comparison with (15)o-labeled water positron emission tomography |
topic | Major Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460128/ https://www.ncbi.nlm.nih.gov/pubmed/30047496 http://dx.doi.org/10.2463/mrms.mp.2018-0003 |
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