Klotho Inhibits Unilateral Ureteral Obstruction-Induced Endothelial-to-Mesenchymal Transition via TGF-β1/Smad2/Snail1 Signaling in Mice

This study aimed to evaluate repression of Klotho on unilateral ureteral obstruction (UUO)-induced renal fibrosis and endothelial-to-mesenchymal transition (EndoMT) in mice. Renal fibrosis model was established by UUO in C57BL/6 male mice. Recombinant Klotho protein was administered to UUO mice as t...

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Detalles Bibliográficos
Autores principales: Li, Shasha, Yu, Lixia, He, Aolin, Liu, Qifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460315/
https://www.ncbi.nlm.nih.gov/pubmed/31024315
http://dx.doi.org/10.3389/fphar.2019.00348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460315/
https://www.ncbi.nlm.nih.gov/pubmed/31024315
http://dx.doi.org/10.3389/fphar.2019.00348

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