Structural insights into a high fidelity variant of SpCas9

The RNA-guided endonucleases of the CRISPR-Cas9 system, including the most widely used Cas9 from Streptococcus pyogenes (SpCas9), are becoming a robust genome editing tool in model organisms and hold immense promise for therapeutic applications. Many strategies have been employed to overcome the lim...

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Detalles Bibliográficos
Autores principales: Guo, Minghui, Ren, Kuan, Zhu, Yuwei, Tang, Ziyun, Wang, Yuhang, Zhang, Bailing, Huang, Zhiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460432/
https://www.ncbi.nlm.nih.gov/pubmed/30664728
http://dx.doi.org/10.1038/s41422-018-0131-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460432/
https://www.ncbi.nlm.nih.gov/pubmed/30664728
http://dx.doi.org/10.1038/s41422-018-0131-6

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