An enrichment method to increase cell-free fetal DNA fraction and significantly reduce false negatives and test failures for non-invasive prenatal screening: a feasibility study

BACKGROUND: Noninvasive prenatal screening (NIPS) based on cell-free fetal DNA (cffDNA) has rapidly been applied into clinic. However, the reliability of this method largely depends on the concentration of cffDNA in the maternal plasma. The chance of test failure results or false negative results wo...

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Detalles Bibliográficos
Autores principales: Hu, Ping, Liang, Dong, Chen, Yangyi, Lin, Ying, Qiao, Fengchang, Li, Hang, Wang, Ting, Peng, Chunfang, Luo, Donghong, Liu, Hailiang, Xu, Zhengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460836/
https://www.ncbi.nlm.nih.gov/pubmed/30975179
http://dx.doi.org/10.1186/s12967-019-1871-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460836/
https://www.ncbi.nlm.nih.gov/pubmed/30975179
http://dx.doi.org/10.1186/s12967-019-1871-x

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