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Endothelial cells secreted endothelin-1 augments diabetic nephropathy via inducing extracellular matrix accumulation of mesangial cells in ETBR(-/-) mice
Endothelin B receptor (ETBR) deficiency may contribute to the progression of diabetic nephropathy (DN) in a streptozotocin (STZ) model, but the underlying mechanism is not fully revealed. In this study, STZ-diabetic ETBR(-/-) mice was characterized by increased serum creatinine and urinary albumin,...
Autores principales: | Zou, Hong-hong, Wang, Li, Zheng, Xiao-xu, Xu, Gao-si, Shen, Yunfeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461170/ https://www.ncbi.nlm.nih.gov/pubmed/30926764 http://dx.doi.org/10.18632/aging.101875 |
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