Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes

Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. The...

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Detalles Bibliográficos
Autores principales: Choi, Yun-Jung, Kang, Min-Hee, Hong, Kwonho, Kim, Jin-Hoi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461172/
https://www.ncbi.nlm.nih.gov/pubmed/30913540
http://dx.doi.org/10.18632/aging.101867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461172/
https://www.ncbi.nlm.nih.gov/pubmed/30913540
http://dx.doi.org/10.18632/aging.101867

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