Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells

Extracellular vesicles (EVs) are known to play important roles in cell-cell communication. Here we investigated the role of muscle-derived EVs and their microRNAs in the loss of bone stem cell populations with age. Aging in male and female C57BL6 mice was associated with a significant increase in ex...

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Detalles Bibliográficos
Autores principales: Fulzele, Sadanand, Mendhe, Bharati, Khayrullin, Andrew, Johnson, Maribeth, Kaiser, Helen, Liu, Yutao, Isales, Carlos M., Hamrick, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461183/
https://www.ncbi.nlm.nih.gov/pubmed/30910993
http://dx.doi.org/10.18632/aging.101874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461183/
https://www.ncbi.nlm.nih.gov/pubmed/30910993
http://dx.doi.org/10.18632/aging.101874

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