Recombinant Marburg viruses containing mutations in the IID region of VP35 prevent inhibition of Host immune responses()

Previous in vitro studies have demonstrated that Ebola and Marburg virus (EBOV and MARV) VP35 antagonize the host cell immune response. Moreover, specific mutations in the IFN inhibitory domain (IID) of EBOV and MARV VP35 that abrogate their interaction with virus-derived dsRNA, lack the ability to...

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Detalles Bibliográficos
Autores principales: Albariño, César G., Guerrero, Lisa Wiggleton, Spengler, Jessica R., Uebelhoer, Luke S., Chakrabarti, Ayan K., Nichol, Stuart T., Towner, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461211/
https://www.ncbi.nlm.nih.gov/pubmed/25531184
http://dx.doi.org/10.1016/j.virol.2014.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461211/
https://www.ncbi.nlm.nih.gov/pubmed/25531184
http://dx.doi.org/10.1016/j.virol.2014.12.002

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