Characterization of MenA (isoprenyl diphosphate:1,4-dihydroxy-2-naphthoate isoprenyltransferase) from Mycobacterium tuberculosis

The menaquinone biosynthetic pathway presents a promising drug target against Mycobacterium tuberculosis and potentially other Gram-positive pathogens. In the present study, the essentiality, steady state kinetics of MenA from M. tuberculosis and the mechanism of MenA inhibition by Ro 48–8071 were c...

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Detalles Bibliográficos
Autores principales: Dhiman, Rakesh K., Pujari, Venugopal, Kincaid, James M., Ikeh, Melanie A., Parish, Tanya, Crick, Dean C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461227/
https://www.ncbi.nlm.nih.gov/pubmed/30978223
http://dx.doi.org/10.1371/journal.pone.0214958

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461227/
https://www.ncbi.nlm.nih.gov/pubmed/30978223
http://dx.doi.org/10.1371/journal.pone.0214958

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