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Pore-forming spider venom peptides show cytotoxicity to hyperpolarized cancer cells expressing K(+) channels: A lentiviral vector approach

Recent studies demonstrated the upregulation of K(+) channels in cancer cells. We have previously found that a pore-forming peptide LaFr26, purified from the venom of the Lachesana sp spider, was selectively incorporated into K(+) channel expressing hyperpolarized cells. Therefore, it is expected th...

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Detalles Bibliográficos
Autores principales: Okada, Masayoshi, Ortiz, Ernesto, Corzo, Gerardo, Possani, Lourival D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461346/
https://www.ncbi.nlm.nih.gov/pubmed/30978253
http://dx.doi.org/10.1371/journal.pone.0215391