Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis

Epithelial barrier loss is a driver of intestinal and systemic diseases. Myosin light chain kinase (MLCK) is a key effector of barrier dysfunction and a potential therapeutic target, but enzymatic inhibition has unacceptable toxicities. Here, we show that a unique domain within the MLCK splice-varia...

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Detalles Bibliográficos
Autores principales: Graham, W Vallen, He, Weiqi, Marchiando, Amanda M., Zha, Juanmin, Singh, Gurminder, Li, Hua-Shan, Biswas, Amlan, Ong, Ma. Lora Drizella M., Jiang, Zhi-Hui, Choi, Wangsun, Zuccola, Harmon, Wang, Yitang, Griffith, James, Wu, Jingshing, Rosenberg, Harry J., Wang, Yingmin, Snapper, Scott B., Ostrov, David, Meredith, Stephen C., Miller, Lawrence W., Turner, Jerrold R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461392/
https://www.ncbi.nlm.nih.gov/pubmed/30936544
http://dx.doi.org/10.1038/s41591-019-0393-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461392/
https://www.ncbi.nlm.nih.gov/pubmed/30936544
http://dx.doi.org/10.1038/s41591-019-0393-7

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