Functional instability allows access to DNA in longer transcription Activator-Like effector (TALE) arrays

Transcription activator-like effectors (TALEs) bind DNA through an array of tandem 34-residue repeats. How TALE repeat domains wrap around DNA, often extending more than 1.5 helical turns, without using external energy is not well understood. Here, we examine the kinetics of DNA binding of TALE arra...

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Detalles Bibliográficos
Autores principales: Geiger-Schuller, Kathryn, Mitra, Jaba, Ha, Taekjip, Barrick, Doug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461438/
https://www.ncbi.nlm.nih.gov/pubmed/30810525
http://dx.doi.org/10.7554/eLife.38298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461438/
https://www.ncbi.nlm.nih.gov/pubmed/30810525
http://dx.doi.org/10.7554/eLife.38298

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