Enzyme activity and selectivity filter stability of ancient TRPM2 channels were simultaneously lost in early vertebrates

Transient Receptor Potential Melastatin 2 (TRPM2) is a cation channel important for the immune response, insulin secretion, and body temperature regulation. It is activated by cytosolic ADP ribose (ADPR) and contains a nudix-type motif 9 (NUDT9)-homology (NUDT9-H) domain homologous to ADPR phosphohy...

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Detalles Bibliográficos
Autores principales: Iordanov, Iordan, Tóth, Balázs, Szollosi, Andras, Csanády, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461439/
https://www.ncbi.nlm.nih.gov/pubmed/30938679
http://dx.doi.org/10.7554/eLife.44556

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461439/
https://www.ncbi.nlm.nih.gov/pubmed/30938679
http://dx.doi.org/10.7554/eLife.44556

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