Cargando…

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen

Acetaminophen (APAP) overdose (APAPo) is predominant in the NIH Pediatric Acute Liver Failure (PALF) Study. We assayed multiple inflammatory mediators in serial serum samples from 13 PALF survivors with APAPo + N-acetylcysteine (NAC, the frontline therapy for APAPo), 8 non-APAPo + NAC, 40 non-APAPo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zamora, Ruben, Barclay, Derek, Yin, Jinling, Alonso, Estella M., Leonis, Mike A., Mi, Qi, Billiar, Timothy R., Simmons, Richard L., Squires, Robert H., Vodovotz, Yoram
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461628/ https://www.ncbi.nlm.nih.gov/pubmed/30979951 http://dx.doi.org/10.1038/s41598-019-42564-5

Ejemplares similares

Dynamics of Systemic Inflammation as a Function of Developmental Stage in Pediatric Acute Liver Failure
por: Vodovotz, Yoram, et al.
Publicado: (2021)

Inferring Tissue-Specific, TLR4-Dependent Type 17 Immune Interactions in Experimental Trauma/Hemorrhagic Shock and Resuscitation Using Computational Modeling
por: Shah, Ashti M., et al.
Publicado: (2022)

Machine Perfusion of Porcine Livers with Oxygen-Carrying Solution Results in Reprogramming of Dynamic Inflammation Networks
por: Sadowsky, David, et al.
Publicado: (2016)

Central Role for MCP-1/CCL2 in Injury-Induced Inflammation Revealed by In Vitro, In Silico, and Clinical Studies
por: Ziraldo, Cordelia, et al.
Publicado: (2013)

Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice
por: Namas, Rami A., et al.
Publicado: (2013)

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice
por: Zamora, Ruben, et al.
Publicado: (2018)

Computational Derivation of Core, Dynamic Human Blunt Trauma Inflammatory Endotypes
por: Schimunek, Lukas, et al.
Publicado: (2021)

MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes
por: Schimunek, Lukas, et al.
Publicado: (2019)

Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma
por: Zaaqoq, Akram M., et al.
Publicado: (2019)

“Thinking” vs. “Talking”: Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress
por: Vodovotz, Yoram, et al.
Publicado: (2017)

Inflammatory signals and network connections implicate cell-mediated immunity in chronic venous insufficiency
por: Vodovotz, Lena, et al.
Publicado: (2021)

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks
por: Zamora, Ruben, et al.
Publicado: (2021)

A putative “chemokine switch” that regulates systemic acute inflammation in humans
por: Azhar, Nabil, et al.
Publicado: (2021)

A Dynamic View of Trauma/Hemorrhage-Induced Inflammation in Mice: Principal Drivers and Networks
por: Mi, Qi, et al.
Publicado: (2011)

Time for trauma immunology
por: Billiar, Timothy R., et al.
Publicado: (2017)

Gender-based reciprocal expression of transforming growth factor-β1 and the inducible nitric oxide synthase in a rat model of cyclophosphamide-induced cystitis
por: Tyagi, Pradeep, et al.
Publicado: (2009)

The Effects of Tacrolimus on Tissue-Specific, Protein-Level Inflammatory Networks in Vascularized Composite Allotransplantation
por: Aral, Ali Mubin, et al.
Publicado: (2021)

Analysis of Serum Inflammatory Mediators Identifies Unique Dynamic Networks Associated with Death and Spontaneous Survival in Pediatric Acute Liver Failure
por: Azhar, Nabil, et al.
Publicado: (2013)

A common single nucleotide polymorphism is associated with inflammation and critical illness outcomes
por: El-Dehaibi, Fayten, et al.
Publicado: (2023)

Central role for neurally dysregulated IL-17A in dynamic networks of systemic and local inflammation in combat casualties
por: Zamora, Ruben, et al.
Publicado: (2023)

HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity
por: Yang, Runkuan, et al.
Publicado: (2014)

Unsupervised Clustering Analysis Based on MODS Severity Identifies Four Distinct Organ Dysfunction Patterns in Severely Injured Blunt Trauma Patients
por: Liu, Dongmei, et al.
Publicado: (2020)

Peripheral nerve repair is associated with augmented cross-tissue inflammation following vascularized composite allotransplantation
por: Shah, Ashti M., et al.
Publicado: (2023)

LONGITUDINAL ANALYSIS OF TRANSCRIPTOMIC SUBTYPES IN TRAUMA PATIENTS
por: Chen, Tianmeng, et al.
Publicado: (2022)

Computational Insights on the Competing Effects of Nitric Oxide in Regulating Apoptosis
por: Bagci, Elife Z., et al.
Publicado: (2008)

HMGB1: Endogenous Danger Signaling
por: Klune, John R, et al.
Publicado: (2008)

Cardiac Arrest Disrupts Caspase-1 and Patterns of Inflammatory Mediators Differently in Skin and Muscle Following Localized Tissue Injury in Rats: Insights from Data-Driven Modeling
por: Starzl, Ravi, et al.
Publicado: (2015)

An Adequately Robust Early TNF-α Response Is a Hallmark of Survival Following Trauma/Hemorrhage
por: Namas, Rajaie, et al.
Publicado: (2009)

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries
por: Almahmoud, Khalid, et al.
Publicado: (2019)

Osteopontin is a multi-faceted pro-tumorigenic driver for central nervous system lymphoma
por: Yushi, Qiu, et al.
Publicado: (2016)

Dynamic Profiling: Modeling the Dynamics of Inflammation and Predicting Outcomes in Traumatic Brain Injury Patients
por: Constantine, Gregory, et al.
Publicado: (2016)

The Acute Inflammatory Response in Trauma / Hemorrhage and Traumatic Brain Injury: Current State and Emerging Prospects
por: Namas, R, et al.
Publicado: (2009)

Protective/reparative cytokines are suppressed at high injury severity in human trauma
por: Cai, Jinman, et al.
Publicado: (2021)

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice
por: Zettel, Kent, et al.
Publicado: (2017)

Insights into the association between coagulopathy and inflammation: abnormal clot mechanics are a warning of immunologic dysregulation following major injury
por: Savage, Stephanie A., et al.
Publicado: (2020)

Elevated Admission Base Deficit Is Associated with a Complex Dynamic Network of Systemic Inflammation Which Drives Clinical Trajectories in Blunt Trauma Patients
por: Abdul-Malak, Othman, et al.
Publicado: (2016)

Defining spatiotemporal gene modules in liver regeneration using Analytical Dynamic Visual Spatial Omics Representation (ADViSOR)
por: Singh-Varma, Anya, et al.
Publicado: (2023)

Neurons Are a Primary Driver of Inflammation via Release of HMGB1
por: Yang, Huan, et al.
Publicado: (2021)

HMGB1 mediates the development of tendinopathy due to mechanical overloading
por: Zhao, Guangyi, et al.
Publicado: (2019)

Plasma proteomics reveals early, broad release of chemokine, cytokine, TNF, and interferon mediators following trauma with delayed increases in a subset of chemokines and cytokines in patients that remain critically ill
por: Bonaroti, Jillian, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_f40j5bbpdmejte0rv6cupge6rc