NDR2 kinase contributes to cell invasion and cytokinesis defects induced by the inactivation of RASSF1A tumor-suppressor gene in lung cancer cells

BACKGROUND: RASSF1A, a tumor suppressor gene, is frequently inactivated in lung cancer leading to a YAP-dependent epithelial-mesenchymal transition (EMT). Such effects are partly due to the inactivation of the anti-migratory RhoB GTPase via the inhibitory phosphorylation of GEF-H1, the GDP/GTP excha...

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Detalles Bibliográficos
Autores principales: Keller, Maureen, Dubois, Fatéméh, Teulier, Sylvain, Martin, Alexandre P. J., Levallet, Jérôme, Maille, Elodie, Brosseau, Solenn, Elie, Nicolas, Hergovich, Alexander, Bergot, Emmanuel, Camonis, Jacques, Zalcman, Gérard, Levallet, Guénaëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461807/
https://www.ncbi.nlm.nih.gov/pubmed/30979377
http://dx.doi.org/10.1186/s13046-019-1145-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461807/
https://www.ncbi.nlm.nih.gov/pubmed/30979377
http://dx.doi.org/10.1186/s13046-019-1145-8

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