The physiological mTOR complex 1 inhibitor DDIT4 mediates therapy resistance in glioblastoma

BACKGROUND: Despite significant advances in the understanding of glioblastoma genetics and biology, survival is still poor. Hypoxia and nutrient depletion in the tumour microenvironment induce adaptive signalling and metabolic responses, which can influence sensitivity to therapeutic regimens. DNA d...

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Detalles Bibliográficos
Autores principales: Foltyn, Martha, Luger, Anna-Luisa, Lorenz, Nadja I., Sauer, Benedikt, Mittelbronn, Michel, Harter, Patrick N., Steinbach, Joachim P., Ronellenfitsch, Michael W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461855/
https://www.ncbi.nlm.nih.gov/pubmed/30745581
http://dx.doi.org/10.1038/s41416-018-0368-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461855/
https://www.ncbi.nlm.nih.gov/pubmed/30745581
http://dx.doi.org/10.1038/s41416-018-0368-3

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