Synergistic antitumour activity of HDAC inhibitor SAHA and EGFR inhibitor gefitinib in head and neck cancer: a key role for ΔNp63α

BACKGROUND: Epidermal growth factor receptor (EGFR) overexpression is associated with the development of head and neck cancer (HNC) and represents one of the main therapeutic targets for this disease. The use of EGFR inhibitors has limited efficacy due to their primary and acquired resistance, parti...

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Detalles Bibliográficos
Autores principales: Citro, Simona, Bellini, Alice, Miccolo, Claudia, Ghiani, Lavinia, Carey, Thomas E., Chiocca, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461861/
https://www.ncbi.nlm.nih.gov/pubmed/30765872
http://dx.doi.org/10.1038/s41416-019-0394-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461861/
https://www.ncbi.nlm.nih.gov/pubmed/30765872
http://dx.doi.org/10.1038/s41416-019-0394-9

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