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M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila

Post-translational modifications such as ubiquitination play a key role in regulation of inflammatory nuclear factor-κB (NF-κB) signalling. The Drosophila IκB kinase γ (IKKγ) Kenny is a central regulator of the Drosophila Imd pathway responsible for activation of the NF-κB Relish. We found the Droso...

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Detalles Bibliográficos
Autores principales: Aalto, Anna L., Mohan, Aravind K., Schwintzer, Lukas, Kupka, Sebastian, Kietz, Christa, Walczak, Henning, Broemer, Meike, Meinander, Annika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462001/
https://www.ncbi.nlm.nih.gov/pubmed/30026495
http://dx.doi.org/10.1038/s41418-018-0164-x