Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

BACKGROUND: Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have be...

Descripción completa

Detalles Bibliográficos
Autores principales: Brodin, Bertha A., Wennerberg, Krister, Lidbrink, Elisabet, Brosjö, Otte, Potdar, Swapnil, Wilson, Jennifer N., Ma, Limin, Moens, Lotte N., Hesla, Asle, Porovic, Edvin, Bernhardsson, Edvin, Papakonstantinou, Antroula, Bauer, Henrik, Tsagkozis, Panagiotis, von Sivers, Karin, Wejde, Johan, Östling, Päivi, Kallioniemi, Olli, Stragliotto, Christina Linder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462037/
https://www.ncbi.nlm.nih.gov/pubmed/30745580
http://dx.doi.org/10.1038/s41416-018-0359-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462037/
https://www.ncbi.nlm.nih.gov/pubmed/30745580
http://dx.doi.org/10.1038/s41416-018-0359-4

Ejemplares similares