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Enzyme annotation for orphan and novel reactions using knowledge of substrate reactive sites

Thousands of biochemical reactions with characterized activities are “orphan,” meaning they cannot be assigned to a specific enzyme, leaving gaps in metabolic pathways. Novel reactions predicted by pathway-generation tools also lack associated sequences, limiting protein engineering applications. As...

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Detalles Bibliográficos
Autores principales: Hadadi, Noushin, MohammadiPeyhani, Homa, Miskovic, Ljubisa, Seijo, Marianne, Hatzimanikatis, Vassily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462048/
https://www.ncbi.nlm.nih.gov/pubmed/30910961
http://dx.doi.org/10.1073/pnas.1818877116