Cargando…
Enzyme annotation for orphan and novel reactions using knowledge of substrate reactive sites
Thousands of biochemical reactions with characterized activities are “orphan,” meaning they cannot be assigned to a specific enzyme, leaving gaps in metabolic pathways. Novel reactions predicted by pathway-generation tools also lack associated sequences, limiting protein engineering applications. As...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462048/ https://www.ncbi.nlm.nih.gov/pubmed/30910961 http://dx.doi.org/10.1073/pnas.1818877116 |