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Neuron-Derived Estrogen Regulates Synaptic Plasticity and Memory

17β-estradiol (E2) is produced from androgens via the action of the enzyme aromatase. E2 is known to be made in neurons in the brain, but its precise functions in the brain are unclear. Here, we used a forebrain-neuron-specific aromatase knock-out (FBN-ARO-KO) mouse model to deplete neuron-derived E...

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Detalles Bibliográficos
Autores principales: Lu, Yujiao, Sareddy, Gangadhara R., Wang, Jing, Wang, Ruimin, Li, Yong, Dong, Yan, Zhang, Quanguang, Liu, Jinyou, O'Connor, Jason C., Xu, Jianhua, Vadlamudi, Ratna K., Brann, Darrell W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462452/
https://www.ncbi.nlm.nih.gov/pubmed/30728170
http://dx.doi.org/10.1523/JNEUROSCI.1970-18.2019