β‐adrenergic‐mediated dynamic augmentation of sarcolemmal Ca(V)1.2 clustering and co‐operativity in ventricular myocytes

KEY POINTS: Prevailing dogma holds that activation of the β‐adrenergic receptor/cAMP/protein kinase A signalling pathway leads to enhanced L‐type Ca(V)1.2 channel activity, resulting in increased Ca(2+) influx into ventricular myocytes and a positive inotropic response. However, the full mechanistic...

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Detalles Bibliográficos
Autores principales: Ito, Danica W., Hannigan, Karen I., Ghosh, Debapriya, Xu, Bing, del Villar, Silvia G., Xiang, Yang K., Dickson, Eamonn J., Navedo, Manuel F., Dixon, Rose E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cardiovascular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462464/
https://www.ncbi.nlm.nih.gov/pubmed/30714156
http://dx.doi.org/10.1113/JP277283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462464/
https://www.ncbi.nlm.nih.gov/pubmed/30714156
http://dx.doi.org/10.1113/JP277283

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