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β‐adrenergic‐mediated dynamic augmentation of sarcolemmal Ca(V)1.2 clustering and co‐operativity in ventricular myocytes

KEY POINTS: Prevailing dogma holds that activation of the β‐adrenergic receptor/cAMP/protein kinase A signalling pathway leads to enhanced L‐type Ca(V)1.2 channel activity, resulting in increased Ca(2+) influx into ventricular myocytes and a positive inotropic response. However, the full mechanistic...

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Detalles Bibliográficos
Autores principales:	Ito, Danica W., Hannigan, Karen I., Ghosh, Debapriya, Xu, Bing, del Villar, Silvia G., Xiang, Yang K., Dickson, Eamonn J., Navedo, Manuel F., Dixon, Rose E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Cardiovascular
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462464/ https://www.ncbi.nlm.nih.gov/pubmed/30714156 http://dx.doi.org/10.1113/JP277283

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