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Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells

Chronic lymphocytic leukemia cells (CLL) migrate between the blood and lymphoid tissues in response to chemokines. Such migration requires structured cytoskeletal-actin polymerization, which may involve the protein cortactin. We discovered that treatment of CLL cells with Wnt5a causes Receptor tyosi...

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Detalles Bibliográficos
Autores principales: Hasan, Md Kamrul, Rassenti, Laura, Widhopf, George F., Yu, Jian, Kipps, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462876/
https://www.ncbi.nlm.nih.gov/pubmed/30568170
http://dx.doi.org/10.1038/s41375-018-0306-7