Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity

Deregulation of the HECT-type ubiquitin ligase E6AP (UBE3A) is implicated in human papilloma virus-induced cervical tumorigenesis and several neurodevelopmental disorders. Yet the structural underpinnings of activity and specificity in this crucial ligase are incompletely understood. Here, we unrave...

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Detalles Bibliográficos
Autores principales: Ries, Lena K., Sander, Bodo, Deol, Kirandeep K., Letzelter, Marie-Annick, Strieter, Eric Robert, Lorenz, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463701/
https://www.ncbi.nlm.nih.gov/pubmed/30737286
http://dx.doi.org/10.1074/jbc.RA118.007014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463701/
https://www.ncbi.nlm.nih.gov/pubmed/30737286
http://dx.doi.org/10.1074/jbc.RA118.007014

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