Targeting V-ATPase Isoform Restores Cisplatin Activity in Resistant Ovarian Cancer: Inhibition of Autophagy, Endosome Function, and ERK/MEK Pathway

Ovarian cancer (OVCA) patients often develop tolerance to standard platinum therapy that accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis-R) display enhanced survival mechanisms to cope with therapeutic stress. In these cells, increased autophagy process assists in chem...

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Detalles Bibliográficos
Autores principales: Kulshrestha, Arpita, Katara, Gajendra K., Ibrahim, Safaa A., Riehl, Valerie, Sahoo, Manoranjan, Dolan, James, Meinke, Kyle W., Pins, Michael R., Beaman, Kenneth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463777/
https://www.ncbi.nlm.nih.gov/pubmed/31057611
http://dx.doi.org/10.1155/2019/2343876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463777/
https://www.ncbi.nlm.nih.gov/pubmed/31057611
http://dx.doi.org/10.1155/2019/2343876

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