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Novel prognostic markers within the CD44‐stromal ligand network in pancreatic cancer

The dense stroma in pancreatic cancer tumours is rich in secreted extracellular matrix proteins and proteoglycans. Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant isoform CD44v6 on cancer cell membranes. Although well esta...

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Detalles Bibliográficos
Autores principales: Franklin, Oskar, Billing, Ola, Öhlund, Daniel, Berglund, Anette, Herdenberg, Carl, Wang, Wanzhong, Hellman, Urban, Sund, Malin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463864/
https://www.ncbi.nlm.nih.gov/pubmed/30456933
http://dx.doi.org/10.1002/cjp2.122