Transcription factor binding site clusters identify target genes with similar tissue-wide expression and buffer against mutations

Background: The distribution and composition of cis-regulatory modules composed of transcription factor (TF) binding site (TFBS) clusters in promoters substantially determine gene expression patterns and TF targets. TF knockdown experiments have revealed that TF binding profiles and gene expression...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Ruipeng, Rogan, Peter K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464064/
https://www.ncbi.nlm.nih.gov/pubmed/31001412
http://dx.doi.org/10.12688/f1000research.17363.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464064/
https://www.ncbi.nlm.nih.gov/pubmed/31001412
http://dx.doi.org/10.12688/f1000research.17363.2

Ejemplares similares