Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections

Antigenic variation is employed by many pathogens to evade the host immune response, and Trypanosoma brucei has evolved a complex system to achieve this phenotype, involving sequential use of variant surface glycoprotein (VSG) genes encoded from a large repertoire of ~2,000 genes. T. brucei express...

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Detalles Bibliográficos
Autores principales: Jayaraman, Siddharth, Harris, Claire, Paxton, Edith, Donachie, Anne-Marie, Vaikkinen, Heli, McCulloch, Richard, Hall, James P. J., Kenny, John, Lenzi, Luca, Hertz-Fowler, Christiane, Cobbold, Christina, Reeve, Richard, Michoel, Tom, Morrison, Liam J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464242/
https://www.ncbi.nlm.nih.gov/pubmed/30943202
http://dx.doi.org/10.1371/journal.pntd.0007262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464242/
https://www.ncbi.nlm.nih.gov/pubmed/30943202
http://dx.doi.org/10.1371/journal.pntd.0007262

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