Cargando…

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections

Antigenic variation is employed by many pathogens to evade the host immune response, and Trypanosoma brucei has evolved a complex system to achieve this phenotype, involving sequential use of variant surface glycoprotein (VSG) genes encoded from a large repertoire of ~2,000 genes. T. brucei express...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayaraman, Siddharth, Harris, Claire, Paxton, Edith, Donachie, Anne-Marie, Vaikkinen, Heli, McCulloch, Richard, Hall, James P. J., Kenny, John, Lenzi, Luca, Hertz-Fowler, Christiane, Cobbold, Christina, Reeve, Richard, Michoel, Tom, Morrison, Liam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464242/ https://www.ncbi.nlm.nih.gov/pubmed/30943202 http://dx.doi.org/10.1371/journal.pntd.0007262

Ejemplares similares

Antigenic Variation in Trypanosoma brucei: Joining the DOTs
por: Stockdale, Chris, et al.
Publicado: (2008)

Divergent metabolism between Trypanosoma congolense and Trypanosoma brucei results in differential sensitivity to metabolic inhibition
por: Steketee, Pieter C., et al.
Publicado: (2021)

Distinct roles for two RAD51-related genes in Trypanosoma brucei antigenic variation
por: Proudfoot, Chris, et al.
Publicado: (2005)

Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms
por: Ali, Juma A. M., et al.
Publicado: (2013)

Influence of the Draining Lymph Nodes and Organized Lymphoid Tissue Microarchitecture on Susceptibility to Intradermal Trypanosoma brucei Infection
por: Alfituri, Omar A., et al.
Publicado: (2020)

Interactions among Trypanosoma brucei RAD51 paralogues in DNA repair and antigenic variation
por: Dobson, Rachel, et al.
Publicado: (2011)

Single molecule analysis of Trypanosoma brucei DNA replication dynamics
por: Calderano, Simone Guedes, et al.
Publicado: (2015)

Trypanosoma brucei and Trypanosoma cruzi DNA Mismatch Repair Proteins Act Differently in the Response to DNA Damage Caused by Oxidative Stress
por: Grazielle-Silva, Viviane, et al.
Publicado: (2020)

Trypanosoma brucei homologous recombination is dependent on substrate length and homology, though displays a differential dependence on mismatch repair as substrate length decreases
por: Barnes, Rebecca L., et al.
Publicado: (2007)

Genome-wide subcellular protein map for the flagellate parasite Trypanosoma brucei
por: Billington, Karen, et al.
Publicado: (2023)

Trypanosoma brucei BRCA2 acts in antigenic variation and has undergone a recent expansion in BRC repeat number that is important during homologous recombination
por: Hartley, Claire L, et al.
Publicado: (2008)

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
por: Briggs, Emma M., et al.
Publicado: (2021)

Diverged composition and regulation of the Trypanosoma brucei origin recognition complex that mediates DNA replication initiation
por: Marques, Catarina A., et al.
Publicado: (2016)

RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse
por: Fernandez-Cortes, Fernando, et al.
Publicado: (2017)

Mapping replication dynamics in Trypanosoma brucei reveals a link with telomere transcription and antigenic variation
por: Devlin, Rebecca, et al.
Publicado: (2016)

Identification of ORC1/CDC6-Interacting Factors in Trypanosoma brucei Reveals Critical Features of Origin Recognition Complex Architecture
por: Tiengwe, Calvin, et al.
Publicado: (2012)

Parasite-driven pathogenesis in Trypanosoma brucei infections
por: Morrison, L J
Publicado: (2011)

Chromosomal copy number variation analysis by next generation sequencing confirms ploidy stability in Trypanosoma brucei subspecies
por: Almeida, Laila Viana, et al.
Publicado: (2018)

Telomeric Expression Sites Are Highly Conserved in Trypanosoma brucei
por: Hertz-Fowler, Christiane, et al.
Publicado: (2008)

Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei
por: McWilliam, Kirsty R., et al.
Publicado: (2019)

Effects of host‐derived chemokines on the motility and viability of Trypanosoma brucei
por: Alfituri, Omar A., et al.
Publicado: (2018)

Trypanosoma brucei ribonuclease H2A is an essential R-loop processing enzyme whose loss causes DNA damage during transcription initiation and antigenic variation
por: Briggs, Emma, et al.
Publicado: (2019)

The Genome Sequence of Trypanosoma brucei gambiense, Causative Agent of Chronic Human African Trypanosomiasis
por: Jackson, Andrew P., et al.
Publicado: (2010)

SUMOylation in Trypanosoma brucei
por: Klein, Cornelia Andrea, et al.
Publicado: (2013)

The exopolyphosphatase TbrPPX1 of Trypanosoma brucei
por: Luginbuehl, Edith, et al.
Publicado: (2011)

A Pre-clinical Animal Model of Trypanosoma brucei Infection Demonstrating Cardiac Dysfunction
por: McCarroll, Charlotte S., et al.
Publicado: (2015)

Trypanosoma evansi is alike to Trypanosoma brucei brucei in the subcellular localisation of glycolytic enzymes
por: Moreno, S Andrea, et al.
Publicado: (2015)

Nucleotide excision repair in Trypanosoma brucei: specialization of transcription-coupled repair due to multigenic transcription
por: Machado, Carlos R, et al.
Publicado: (2014)

Genome-wide Analysis Reveals Extensive Functional Interaction between DNA Replication Initiation and Transcription in the Genome of Trypanosoma brucei
por: Tiengwe, Calvin, et al.
Publicado: (2012)

Trypanosoma brucei ATR Links DNA Damage Signaling during Antigenic Variation with Regulation of RNA Polymerase I-Transcribed Surface Antigens
por: Black, Jennifer Ann, et al.
Publicado: (2020)

Dermal bacterial LPS-stimulation reduces susceptibility to intradermal Trypanosoma brucei infection
por: Alfituri, Omar A., et al.
Publicado: (2021)

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei
por: Stortz, Jennifer A., et al.
Publicado: (2017)

Evaluation of In Vitro Activity of Essential Oils against Trypanosoma brucei brucei and Trypanosoma evansi
por: Habila, Nathan, et al.
Publicado: (2010)

A Major Genetic Locus in Trypanosoma brucei Is a Determinant of Host Pathology
por: Morrison, Liam J., et al.
Publicado: (2009)

RAD51-mediated R-loop formation acts to repair transcription-associated DNA breaks driving antigenic variation in Trypanosoma brucei
por: Girasol, Mark John, et al.
Publicado: (2023)

Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole
por: Steketee, Pieter C., et al.
Publicado: (2021)

C-Terminal Mutants of Apolipoprotein L-I Efficiently Kill Both Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
por: Lecordier, Laurence, et al.
Publicado: (2009)

De Novo Genome Assembly Shows Genome Wide Similarity between Trypanosoma brucei brucei and Trypanosoma brucei rhodesiense
por: Sistrom, Mark, et al.
Publicado: (2016)

Cellular landmarks of Trypanosoma brucei and Leishmania mexicana
por: Halliday, Clare, et al.
Publicado: (2019)

Golgi duplication in Trypanosoma brucei
por: He, Cynthia Y., et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_luboip2i7n73308sajq7kkloeh