A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B

BACKGROUND: Leishmania donovani is a protozoan parasite, a primary causative agent of visceral leishmaniasis. Sterol produced via the mevalonate pathway, show differences in composition across biological kingdoms. The specific occurrence of Δ22-unsaturated sterols, containing a double bond at the C-...

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Detalles Bibliográficos
Autores principales: Bansal, Ruby, Sen, Shib Sankar, Muthuswami, Rohini, Madhubala, Rentala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464246/
https://www.ncbi.nlm.nih.gov/pubmed/30943203
http://dx.doi.org/10.1371/journal.pntd.0007260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464246/
https://www.ncbi.nlm.nih.gov/pubmed/30943203
http://dx.doi.org/10.1371/journal.pntd.0007260

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