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An ATF3-CreERT2 Knock-In Mouse for Axotomy-Induced Genetic Editing: Proof of Principle

Genome editing techniques have facilitated significant advances in our understanding of fundamental biological processes, and the Cre-Lox system has been instrumental in these achievements. Driving Cre expression specifically in injured neurons has not been previously possible: we sought to address...

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Detalles Bibliográficos
Autores principales: Holland, Seth D., Ramer, Leanne M., McMahon, Stephen B., Denk, Franziska, Ramer, Matt S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464513/
https://www.ncbi.nlm.nih.gov/pubmed/30993183
http://dx.doi.org/10.1523/ENEURO.0025-19.2019