The Metabolomic Signature of Opa1 Deficiency in Rat Primary Cortical Neurons Shows Aspartate/Glutamate Depletion and Phospholipids Remodeling

Pathogenic variants of OPA1, which encodes a dynamin GTPase involved in mitochondrial fusion, are responsible for a spectrum of neurological disorders sharing optic nerve atrophy and visual impairment. To gain insight on OPA1 neuronal specificity, we performed targeted metabolomics on rat cortical n...

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Detalles Bibliográficos
Autores principales: Chao de la Barca, Juan Manuel, Arrázola, Macarena S., Bocca, Cinzia, Arnauné-Pelloquin, Laetitia, Iuliano, Olga, Tcherkez, Guillaume, Lenaers, Guy, Simard, Gilles, Belenguer, Pascale, Reynier, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465244/
https://www.ncbi.nlm.nih.gov/pubmed/30988455
http://dx.doi.org/10.1038/s41598-019-42554-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465244/
https://www.ncbi.nlm.nih.gov/pubmed/30988455
http://dx.doi.org/10.1038/s41598-019-42554-7

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