Mechanism of the electroneutral sodium/proton antiporter PaNhaP from transition-path shooting

Na(+)/H(+) antiporters exchange sodium ions and protons on opposite sides of lipid membranes. The electroneutral Na(+)/H(+) antiporter NhaP from archaea Pyrococcus abyssi (PaNhaP) is a functional homolog of the human Na(+)/H(+) exchanger NHE1, which is an important drug target. Here we resolve the N...

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Detalles Bibliográficos
Autores principales: Okazaki, Kei-ichi, Wöhlert, David, Warnau, Judith, Jung, Hendrik, Yildiz, Özkan, Kühlbrandt, Werner, Hummer, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465308/
https://www.ncbi.nlm.nih.gov/pubmed/30988359
http://dx.doi.org/10.1038/s41467-019-09739-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465308/
https://www.ncbi.nlm.nih.gov/pubmed/30988359
http://dx.doi.org/10.1038/s41467-019-09739-0

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