Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation

RIPK1 regulates cell death and inflammation through kinase-dependent and -independent mechanisms. As a scaffold, RIPK1 inhibits caspase-8-dependent apoptosis and RIPK3/MLKL-dependent necroptosis. As a kinase, RIPK1 paradoxically induces these cell death modalities. The molecular switch between RIPK1...

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Detalles Bibliográficos
Autores principales: Dondelinger, Yves, Delanghe, Tom, Priem, Dario, Wynosky-Dolfi, Meghan A., Sorobetea, Daniel, Rojas-Rivera, Diego, Giansanti, Piero, Roelandt, Ria, Gropengiesser, Julia, Ruckdeschel, Klaus, Savvides, Savvas N., Heck, Albert J. R., Vandenabeele, Peter, Brodsky, Igor E., Bertrand, Mathieu J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465317/
https://www.ncbi.nlm.nih.gov/pubmed/30988283
http://dx.doi.org/10.1038/s41467-019-09690-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465317/
https://www.ncbi.nlm.nih.gov/pubmed/30988283
http://dx.doi.org/10.1038/s41467-019-09690-0

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