CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

Cyclin-dependent kinase 12 (CDK12) modulates transcription elongation by phosphorylating the carboxy-terminal domain of RNA polymerase II and selectively affects the expression of genes involved in the DNA damage response (DDR) and mRNA processing. Yet, the mechanisms underlying such selectivity rem...

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Detalles Bibliográficos
Autores principales: Krajewska, Malgorzata, Dries, Ruben, Grassetti, Andrew V., Dust, Sofia, Gao, Yang, Huang, Hao, Sharma, Bandana, Day, Daniel S., Kwiatkowski, Nicholas, Pomaville, Monica, Dodd, Oliver, Chipumuro, Edmond, Zhang, Tinghu, Greenleaf, Arno L., Yuan, Guo-Cheng, Gray, Nathanael S., Young, Richard A., Geyer, Matthias, Gerber, Scott A., George, Rani E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465371/
https://www.ncbi.nlm.nih.gov/pubmed/30988284
http://dx.doi.org/10.1038/s41467-019-09703-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465371/
https://www.ncbi.nlm.nih.gov/pubmed/30988284
http://dx.doi.org/10.1038/s41467-019-09703-y

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