Differential Regulation of Gene Expression in Lung Cancer Cells by Diacyglycerol-Lactones and a Phorbol Ester Via Selective Activation of Protein Kinase C Isozymes

Despite our extensive knowledge on the biology of protein kinase C (PKC) and its involvement in disease, limited success has been attained in the generation of PKC isozyme-specific modulators acting via the C1 domain, the binding site for the lipid second messenger diacylglycerol (DAG) and the phorb...

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Detalles Bibliográficos
Autores principales: Cooke, Mariana, Casado-Medrano, Victoria, Ann, Jihyae, Lee, Jeewoo, Blumberg, Peter M., Abba, Martin C., Kazanietz, Marcelo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465381/
https://www.ncbi.nlm.nih.gov/pubmed/30988374
http://dx.doi.org/10.1038/s41598-019-42581-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465381/
https://www.ncbi.nlm.nih.gov/pubmed/30988374
http://dx.doi.org/10.1038/s41598-019-42581-4

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