Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells

(+)-JQ1 is an inhibitor of the tumor-driver bromodomain protein BRD4 and produces satisfactory effects because it efficiently increases apoptosis. Ferroptosis is an oxidative cell death program differing from apoptosis. Ferroptosis is characterized by high levels of iron and reactive oxygen species...

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Detalles Bibliográficos
Autores principales: Sui, Shiyao, Zhang, Jian, Xu, Shouping, Wang, Qin, Wang, Peiyuan, Pang, Da
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465411/
https://www.ncbi.nlm.nih.gov/pubmed/30988278
http://dx.doi.org/10.1038/s41419-019-1564-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465411/
https://www.ncbi.nlm.nih.gov/pubmed/30988278
http://dx.doi.org/10.1038/s41419-019-1564-7

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