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Fragment Hits: What do They Look Like and How do They Bind?
[Image: see text] A “fragment hit”, a molecule of low molecular weight that has been validated to bind to a target protein, can be an effective chemical starting point for a drug discovery project. Our ability to find and progress fragment hits could potentially be improved by enhancing our understa...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466478/ https://www.ncbi.nlm.nih.gov/pubmed/30875465 http://dx.doi.org/10.1021/acs.jmedchem.8b01855 |