Cargando…
Fragment Hits: What do They Look Like and How do They Bind?
[Image: see text] A “fragment hit”, a molecule of low molecular weight that has been validated to bind to a target protein, can be an effective chemical starting point for a drug discovery project. Our ability to find and progress fragment hits could potentially be improved by enhancing our understa...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466478/ https://www.ncbi.nlm.nih.gov/pubmed/30875465 http://dx.doi.org/10.1021/acs.jmedchem.8b01855 |