Cargando…

Fragment Hits: What do They Look Like and How do They Bind?

[Image: see text] A “fragment hit”, a molecule of low molecular weight that has been validated to bind to a target protein, can be an effective chemical starting point for a drug discovery project. Our ability to find and progress fragment hits could potentially be improved by enhancing our understa...

Descripción completa

Detalles Bibliográficos
Autores principales: Giordanetto, Fabrizio, Jin, Chentian, Willmore, Lindsay, Feher, Miklos, Shaw, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466478/
https://www.ncbi.nlm.nih.gov/pubmed/30875465
http://dx.doi.org/10.1021/acs.jmedchem.8b01855