Genome sequencing analysis of blood cells identifies germline haplotypes strongly associated with drug resistance in osteosarcoma patients

BACKGROUND: Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective therapy. Genetic variation contributes to a wide range of response and toxicity...

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Detalles Bibliográficos
Autores principales: Bhuvaneshwar, Krithika, Harris, Michael, Gusev, Yuriy, Madhavan, Subha, Iyer, Ramaswamy, Vilboux, Thierry, Deeken, John, Yang, Elizabeth, Shankar, Sadhna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466653/
https://www.ncbi.nlm.nih.gov/pubmed/30991985
http://dx.doi.org/10.1186/s12885-019-5474-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466653/
https://www.ncbi.nlm.nih.gov/pubmed/30991985
http://dx.doi.org/10.1186/s12885-019-5474-y

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