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OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair

BACKGROUND: Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deubiquitinase 4 (OTUD4) has been reported involved in DNA damage repair pathways a...

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Detalles Bibliográficos
Autores principales: Wu, Zhiqiang, Qiu, Minghan, Guo, Yu, Zhao, Jinlin, Liu, Zhuang, Wang, Hui, Meng, Maobin, Yuan, Zhiyong, Mi, Zeyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466656/
https://www.ncbi.nlm.nih.gov/pubmed/31011293
http://dx.doi.org/10.1186/s12935-019-0816-z