Cargando…

OTU deubiquitinase 4 is silenced and radiosensitizes non-small cell lung cancer cells via inhibiting DNA repair

BACKGROUND: Radiotherapy is becoming one major therapeutics for non-small cell lung cancer (NSCLC). Identifying novel radiosensitizers will greatly increase the efficacy of radiotherapy and benefit more patients. OTU deubiquitinase 4 (OTUD4) has been reported involved in DNA damage repair pathways a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Zhiqiang, Qiu, Minghan, Guo, Yu, Zhao, Jinlin, Liu, Zhuang, Wang, Hui, Meng, Maobin, Yuan, Zhiyong, Mi, Zeyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466656/ https://www.ncbi.nlm.nih.gov/pubmed/31011293 http://dx.doi.org/10.1186/s12935-019-0816-z

Ejemplares similares

WT1‐interacting protein inhibits cell proliferation and tumorigenicity in non‐small‐cell lung cancer via the AKT/FOXO1 axis
por: Wu, Zhiqiang, et al.
Publicado: (2019)

Identification and characterization of diverse OTU deubiquitinases in bacteria
por: Schubert, Alexander F, et al.
Publicado: (2020)

Depleting PTOV1 sensitizes non-small cell lung cancer cells to chemotherapy through attenuating cancer stem cell traits
por: Wu, Zhiqiang, et al.
Publicado: (2019)

Viral OTU Deubiquitinases: A Structural and Functional Comparison
por: Bailey-Elkin, Ben A., et al.
Publicado: (2014)

Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii
por: Wilde, Mary-Louise, et al.
Publicado: (2023)

Regulation of A20 and other OTU deubiquitinases by reversible oxidation
por: Kulathu, Yogesh, et al.
Publicado: (2013)

Bacterial OTU deubiquitinases regulate substrate ubiquitination upon Legionella infection
por: Shin, Donghyuk, et al.
Publicado: (2020)

OTU deubiquitinase 5 inhibits the progression of non‐small cell lung cancer via regulating p53 and PDCD5
por: Kang, Xiao‐yun, et al.
Publicado: (2020)

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis
por: Mevissen, Tycho E.T., et al.
Publicado: (2013)

STAT3/miR-135b/NF-κB axis confers aggressiveness and unfavorable prognosis in non-small-cell lung cancer
por: Zhao, Jinlin, et al.
Publicado: (2021)

Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA
por: Luo, Jiwei, et al.
Publicado: (2022)

SPATA2 suppresses epithelial‐mesenchymal transition to inhibit metastasis and radiotherapy sensitivity in non–small cell lung cancer via impairing DVL1/β‐catenin signaling
por: Ji, Hongbo, et al.
Publicado: (2023)

Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity
por: Dzimianski, John V., et al.
Publicado: (2019)

Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells
por: Lin, Yanzhu, et al.
Publicado: (2019)

IFI35 is involved in the regulation of the radiosensitivity of colorectal cancer cells
por: Hu, Yan, et al.
Publicado: (2021)

Histone Deubiquitinase OTU1 Epigenetically Regulates DA1 and DA2, Which Control Arabidopsis Seed and Organ Size
por: Keren, Ido, et al.
Publicado: (2020)

Silencing SATB1 with siRNA inhibits the proliferation and invasion of small cell lung cancer cells
por: Huang, Bo, et al.
Publicado: (2013)

dbOTU3: A new implementation of distribution-based OTU calling
por: Olesen, Scott W., et al.
Publicado: (2017)

Experimental study on the regulation of erlotinib-induced radiosensitization with an anti-c-MET monoclonal antibody
por: Zhuang, Hong-Qing, et al.
Publicado: (2014)

The radiosensitization effects of Endostar on human lung squamous cancer cells H-520
por: You, Zhen Y, et al.
Publicado: (2010)

Effect of Ku70 expression on radiosensitivity in renal carcinoma 786-O cells
por: Qi, Defeng, et al.
Publicado: (2014)

EGFR inhibitor C225 increases the radiosensitivity of human lung squamous cancer cells
por: Zhang, Yingdong, et al.
Publicado: (2010)

The Ibr-7 derivative of ibrutinib radiosensitizes pancreatic cancer cells by downregulating p-EGFR
por: Tan, Biqin, et al.
Publicado: (2020)

The histone deacetylase inhibitor PCI-24781 as a putative radiosensitizer in pediatric glioblastoma cell lines
por: de Andrade, Pamela Viani, et al.
Publicado: (2016)

SOCS6 promotes radiosensitivity and decreases cancer cell stemness in esophageal squamous cell carcinoma by regulating c-Kit ubiquitylation
por: Sun, Xuanzi, et al.
Publicado: (2021)

RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG(2) human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell
por: Zhao, Yan, et al.
Publicado: (2013)

pATM and γH2AX are effective radiation biomarkers in assessing the radiosensitivity of (12)C(6+) in human tumor cells
por: Zhao, Jin, et al.
Publicado: (2017)

Silencing SHMT2 inhibits the progression of tongue squamous cell carcinoma through cell cycle regulation
por: Liao, Yan, et al.
Publicado: (2021)

Distinct expression and prognostic value of OTU domain-containing proteins in non-small-cell lung cancer
por: Deng, Jingjing, et al.
Publicado: (2019)

Sufferings in silence: Violence against female workers in the ready-made garment industry in Bangladesh: A qualitative exploration
por: Akhter, Sadika, et al.
Publicado: (2019)

On the use of sequence-quality information in OTU clustering
por: Müller, Robert, et al.
Publicado: (2021)

Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells
por: Yang, Yan, et al.
Publicado: (2020)

Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis
por: Hagen, Katie R, et al.
Publicado: (2013)

Usp5, Usp34, and Otu1 deubiquitylases mediate DNA repair in Drosophila melanogaster
por: Páhi, Zoltán G., et al.
Publicado: (2022)

CDA gene silencing regulated the proliferation and apoptosis of chronic myeloid leukemia K562 cells
por: Wei, Xiao-Fang, et al.
Publicado: (2018)

CTCF-silenced miR-137 contributes to EMT and radioresistance in esophageal squamous cell carcinoma
por: Xu, Shuwen, et al.
Publicado: (2021)

Silencing of heat shock protein 27 increases the radiosensitivity of non-small cell lung carcinoma cells
por: Xu, Liping, et al.
Publicado: (2019)

Circular RNA circPITX1 knockdown inhibits glycolysis to enhance radiosensitivity of glioma cells by miR-329-3p/NEK2 axis
por: Guan, Yongchang, et al.
Publicado: (2020)

Influence on the behavior of lung cancer H1299 cells by silencing SLC35F2 expression
por: Li, Xiao, et al.
Publicado: (2013)

Silencing of TRIM11 suppresses the tumorigenicity of chordoma cells through improving the activity of PHLPP1/AKT
por: Wang, Bin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vtn60urcv0r4iv45nidb81smil