DNMT and HDAC inhibitors modulate MMP-9-dependent H3 N-terminal tail proteolysis and osteoclastogenesis

BACKGROUND: MMP-9-dependent proteolysis of histone H3 N-terminal tail (H3NT) is an important mechanism for activation of gene expression during osteoclast differentiation. Like other enzymes targeting their substrates within chromatin structure, MMP-9 enzymatic activity toward H3NT is tightly contro...

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Detalles Bibliográficos
Autores principales: Shin, Yonghwan, Ghate, Nikhil B., Moon, Byoungsan, Park, Kyungpyo, Lu, Wange, An, Woojin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466663/
https://www.ncbi.nlm.nih.gov/pubmed/30992059
http://dx.doi.org/10.1186/s13072-019-0270-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466663/
https://www.ncbi.nlm.nih.gov/pubmed/30992059
http://dx.doi.org/10.1186/s13072-019-0270-0

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