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Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression
BACKGROUND: Neural tube defects (NTDs) are common birth defects involving the central nervous system. Recent studies on the etiology of human NTDs have raised the possibility that epigenetic regulation could be involved in determining susceptibility to them. RESULTS: Here, we show that the H2AK119ub...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466687/ https://www.ncbi.nlm.nih.gov/pubmed/30992047 http://dx.doi.org/10.1186/s13072-019-0268-7 |