A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence

BACKGROUND: Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic phenotypes of replicative cellular aging. This accelerated or therapy-induced senescence has been alternatively proposed to contribute to thera...

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Detalles Bibliográficos
Autores principales: Wu, Ding, Pepowski, Brett, Takahashi, Satoe, Kron, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466706/
https://www.ncbi.nlm.nih.gov/pubmed/30987592
http://dx.doi.org/10.1186/s12864-019-5653-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466706/
https://www.ncbi.nlm.nih.gov/pubmed/30987592
http://dx.doi.org/10.1186/s12864-019-5653-x

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