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A cmap-enabled gene expression signature-matching approach identifies small-molecule inducers of accelerated cell senescence
BACKGROUND: Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic phenotypes of replicative cellular aging. This accelerated or therapy-induced senescence has been alternatively proposed to contribute to thera...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466706/ https://www.ncbi.nlm.nih.gov/pubmed/30987592 http://dx.doi.org/10.1186/s12864-019-5653-x |